This Twitter account is for relevant preprints of academic papers on publicly-available servers. connect.biorxiv.org/relate/c…

Rochester, MN
Joined March 2020
Primary and secondary outcomes comparison found differences not to be statistically significant
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2/3 Figure 1 depicts flow chart of Chinese protocols for recovered donor recruitment, plasma collection, plasma examination, and administration of convalescent plasma therapy
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SARS-CoV-19 Preprints retweeted
This is good news indeed. What does the curve for NYC look like ?
The California #COVID19 story is an unexplained, very positive one, w/ early physical distancing early offered as the 1° driver. The apex for hospitalizations hit today, for death expected Wednesday. Way below the @IHME_UW model predictions graphics via @ms_gilchrist @sdut
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SARS-CoV-19 Preprints retweeted
A lot of people are wondering why #Japan has so few cases of #COVID19. In this commentary, @NathanGrubaugh and I speculate on some possible reasons. (1/n) embopress.org/doi/10.15252/e…
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SARS-CoV-19 Preprints retweeted
I made a Table on the striking differences in COVID deaths in 6 countries 1) Case fatality rate differences partly explained by testing frequency: except Italy— reflects overwhelmed system? 2) Deaths/million: likely reflects extent of spread in a country @PSampathkumarMD @choo_ek
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SARS-CoV-19 Preprints retweeted
New results from a (small) pilot study of convalescent plasma therapy for COVID-19: pnas.org/content/early/2020/… Published without embargo due to immediate relevance. PNAS ⬇️
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10/11 Limitations: -Current lack of peer review (pre-print) -Lack of information about the kinetics of viral loads (lacked respiratory specimens) -Patients in severe and critical condition were excluded from the study (received passive antibody treatment before sample collection)
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9/11 Despite 77.2% identical amino acids between SARS-CoV-2 and SARS-CoV spike proteins and cross-binding potential, COVID-19 convalescent plasma did NOT neturalize SARS-CoV, suggesting differences between #SARSCoV2 and #SARSCoV #epitopes and #immunogenicity
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8/11 NAb titers negatively correlated with blood lymphocyte counts and positively correlated with blood CRP levels, suggesting that the humoral response might play an important role when cellular response is dysfunctional or impaired.
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7/11 NAb titers in ten of the 175 recovered patients were below limit of detection despite lab-confirmed infection with SARS-CoV-2
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6/11 Neutralizing antibody titers of COVID-19 patients collected two weeks post-discharge did not significantly differ from those collected at the time of discharge
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5/11 Temporal analysis of COVID19 antibody titers shows humoral immune response ramping up on day 10-15 post-onset of disease
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4/11 Older COVID19-recovered patients demonstrated higher titers of both neutralizing and spike-binding #SARSCoV2-specific #antibodies
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3/11 ~30% of COVID19-recovered patients failed to develop high titers of neutralizing antibodies despite similar disease duration, suggesting key role of T-cells or cytokines in immune response
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2/11 A pseudotyped-lentiviral-vector-based neutralization assay was used to measure SARS-CoV-2-specific neutralizing antibodies (NAbs) in plasma from recovered COVID-19 patients with mild symptoms
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